It was the largest slave rebellion in the United States. That is pretty insignificant because no slave rebellion ever amounted to a serious threat to the system

On January 8, 1811 the slaves of the Woodland sugar plantation, then owned by John Andry, killed Andry's son, wounded Andry and walked off the plantation seeking emancipation. The Andry Plantation was about 40 miles west of New Orleans in St. John Parish near LaPlace. The slave, Charles Deslondes is listed as the leader of the rebellion. Marching east towards New Orleans they collected additional slaves from plantations along the way, including the Destrehan Plantation. Their ranks grew to 500 before they were stopped by local militia led by Andry amd chased into the swamps. Ultimately on January 11th a US Military contingent led by General Wade Hampton arrived (much like FEMA, a day late and a dollar short).  About 100 slaves were either killed in the confrontation or executed later by the authorities.

It's no coincidence that this slave revolt took place two years after the massive influx of Hatians to the city in 1809. From Wikipedia's Haiti:

The new State of Haiti [in 1804] supported the abolitionist cause wherever possible. Haiti aided Francisco de Miranda and Simón Bolívar, giving them refuge and supporting their revolutionary efforts under the condition he free Latin America's slaves. The slaveholding powers surrounding Haiti isolated the new nation under a cordon sanitaire, fearing slave revolutions of their own. The Haitian Revolution is thought to have inspired numerous slave revolts in the Caribbean and United States